This urgent appeal from scholars at academic institutions calls for U.S. involvement and mediation as an imperative step towards resolving the crisis in the Republic of Artsakh (Nagorno-Karabakh). We deplore the recent agreement between Russia, Armenia, and Azerbaijan that Armenia and Artsakh were forced to sign and that circumvents the Minsk Group. Without U.S. engagement, we believe the threat of continued ethnic cleansing and genocide remains.