Twesigye Jackson Kaguri was born and raised in Uganda in the village of Nyakagyezi. A graduate of Makerere University, Kaguri co-founded the human rights organization, Human Rights Concerns, to help victims of human rights violations in Uganda and to educate the public about their rights. In 2001, he founded the Nyaka AIDS Orphans Project in response to the devastating effects of AIDS in his hometown. The organization provides free education to children who have lost one or both parents to HIV/AIDS.